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Off-axis reference beam for full-field swept-source OCT and holoscopy

机译:用于全场扫描光源OCT和全息透视的离轴参考光束

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摘要

In numerous applications, Fourier-domain optical coherence tomography(FD-OCT) suffers from a limited imaging depth due to signal roll-off, a limitedfocal range, and autocorrelation noise. Here, we propose a parallel full-fieldFD-OCT imaging method that uses a swept laser source and an area camera incombination with an off-axis reference, which is incident on the camera at asmall angle. As in digital off-axis holography, this angle separatesautocorrelation signals and the complex conjugated mirror image from the actualsignal in Fourier space. We demonstrate that by reconstructing the signal termonly, this approach enables full-range imaging, i.e., it increases the imagingdepth by a factor of two, and removes autocorrelation artifacts. The previouslydemonstrated techniques of inverse scattering and holoscopy can thennumerically extend the focal range without loss of lateral resolution orimaging sensitivity. The resulting, significantly enhanced measurement depth isdemonstrated by imaging a porcine eye over its entire depth, including cornea,lens, and retina. Finally, the feasibility of in vivo measurements isdemonstrated by imaging the living human retina.
机译:在许多应用中,傅立叶域光学相干断层扫描(FD-OCT)由于信号滚降,有限的焦距范围和自相关噪声而受到成像深度的限制。在这里,我们提出了一种平行全场FD-OCT成像方法,该方法使用扫频激光源和面照相机与离轴参考相结合,并以小角度入射到照相机上。与数字离轴全息术一样,该角度将自相关信号和复共轭镜像与傅立叶空间中的实际信号分开。我们证明了通过仅重建信号项,这种方法可以实现全范围成像,即它将成像深度增加两倍,并消除了自相关伪像。然后,先前展示的逆散射和全息术技术可以在不损失横向分辨率或成像灵敏度的情况下以数字方式扩展焦距范围。通过对猪眼的整个深度(包括角膜,晶状体和视网膜)进行成像,可以证明所得到的显着增强的测量深度。最后,通过对活的人类视网膜成像来证明体内测量的可行性。

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